课题组长：储剑虹
课题组成员包括技术员1名，在读研究生4 名。主要研究方向：1. 血液系统肿瘤免疫治疗的基础研究与临床应用；2. 自然杀伤细胞的成熟及其抗肿瘤效应的分子调控机制。目前在研国家自然科学基金面上项目一项，在Immunity、Blood、Leukemia 和Clinical Cancer Research 等学术期刊发表论文三十余篇。
代表性成果：
论文
1. Chen L, Mao H, Zhang J, Chu J, Devine S, Caligiuri MA, Yu J. Targeting FLT3by chimericantigen receptor T cells for the treatment of acute myeloidleukemia. Leukemia. 2017;31(8):1830-1834.
2. Deng Y#, Kerdiles Y#, Chu J#, et al. Deng Y, Kerdiles Y, Chu J, Yuan S, Wang Y,Chen X, Mao H, Zhang L, Zhang J, Hughes T, Deng Y, Zhang Q, Wang F, ZouX, Liu CG, Freud AG, Li X, Caligiuri MA*, Vivier E*, Yu J*. Transcription factor Foxo1 is a Negative Regulator of Natural killer Cell Maturation and Function. Immunity. 2015;42(3):457-470.
3. Chu J#, Deng Y #, Benson DM, He S, Hughes T, Zhang J, Peng Y, Mao H, Yi L, Ghoshal K, He X, Devine SM, Zhang X, Caligiuri MA, Hofmeister CC*, Yu J*. CS1-Specific Chimeric Antigen Receptor (CAR)-Engineered Natural Killer Cells Enhance In Vitro and In Vivo Anti-tumor Activity Against Human Multiple Myeloma. Leukemia. 2014;28(4):917-27.
4. Chu J#, He S#, Deng Y#, Zhang J, Peng Y, Hughes T, Yi L, Kwon CH, Wang QE, Devine SM, He X, Bai XF, Hofmeister CC*, Yu J*. Genetic Modification of T cells Redirected towards CS1 Enhances Anti-Myeloma activity. Clinical Cancer Research. 2014;20(15): 3989-4000.
5. Deng Y#, Chu J#, Ren Y#, Fan Z, Ji X, Mundy-Bosse B, Yuan S, Hughes T, Zhang J, Cheema B, Camardo AT, Xia Y, Wu LC, Wang LS, He X, Kinghorn AD, Li X, Caligiuri MA*, Yu J*. The Natural Product Phyllanthusmin C Enhances IFN-γ Production by Human Natural Killer Cells through Upregulation of TLRmediated NF-kappaB Signaling. Journal of Immunology. 2014;193(6):2994-3002.
6. He S, Chu J, Wu LC, Mao H, Peng Y, Alvarez-Breckenridge CA, Hughes T, Wei M, Zhang J,Yuan S, Sandhu S, Vasu S, Benson DM Jr, Hofmeister CC, He X, Ghoshal K, Devine SM, Caligiuri MA, Yu J. MicroRNAs activate natural killer cells through Toll-like receptor signaling. Blood. 2013;121(23):4663-71.
专利
CS1-specific Chimeric Antigen Receptor (CAR) Engineered Immune Cells. Jianhua Yu, Hofmeister Craig and Jianhong Chu. PCT 国际专利（ 编号: PCT/ US2014/036684. WO2014/179759）