课题组长：何苏丹

课题组主要研究程序性细胞死亡的分子机制与功能，发现了Toll 样受体介导的细胞程序性坏死新通路及其在抗感染免疫应答中的作用，揭示了细胞程序性坏死在病原体HSV 感染中的启动机制和抗病毒的生物学功能，发现了调节细胞死亡的小分子化合物及其作用机理与抗肿瘤功能。相关论文发表于重要国际学术期刊Cell、PNAS、Nature Communications、Journal of Virology 和Biomaterials 等。课题组成员作为项目负责人获得“国家优秀青年科学基金”、 “江苏省杰出青年科学基金”， “霍英东青年教师基金”等资助，还作为子课题负责人承担一项国家重点科学研究计划，入选教育部长江学者奖励计划青年学者、 江苏省“六大人才高峰”和“333 高层次人才培养工程”。

代表性成果 Representative Achievements(*Corresponding authors)：

论文

1. Yang C#, Li J#, Yu L#, Zhang Z, Xu F, Jiang L, Zhou X*, He S*.Regulation of RIP3 by thetranscription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis. Cell Death Dis.2017;8(10):e3084.

2. Cao Z, Peng F, Hu Z, Chu B, Zhong Y, Su Y*, He S*, He Y*.In vitro cellular behaviors and toxicity assays of small-sized fluorescent silicon nanoparticles. Nanoscale. 2017;9 (22):7602-7611.

3. Hu Z#, Song B#, Xu L, Zhong Y, Peng F, Ji X, Zhu F, Yang C, Zhou J, Su Y, Chen S, He Y*, He S*. Aqueous synthesized quantum dots interfere with the NF-κB pathway and confer anti-tumor, anti-viral and anti-inflammatory effects. Biomaterials 2016;108:187-96.

4. Dong T#, Li C#, Wang X, Dian L, Zhang X, Li L, Chen S, Cao R, Li L, Huang N, He S*,Lei X*. Ainsliadimer a selectively inhibits IKKα/β by covalently binding a conserved cysteine. Nat Commun 2015;6:6522.

5. Yu X, Li Y, Chen Q, Su C, Zhang Z, Yang C, Hu Z, Hou J, Zhou J, Gong L, Jiang X,Zheng C*, He S*. Herpes simplex virus Type 1 (HSV-1) and HSV-2 mediate species specific modulations of programmed necrosis through the viral ribonucleotide reductase large subunit R1. J Virol 2015;90:1088-95. 6.Wang X#, Li Y#, Liu S#, Yu X#, Li L, Shi C, He W, Li J, Xu L, Hu Z, Yu L, Yang Z, Chen Q, Ge L, Zhang Z, Zhou B, Jiang X, Chen S, He S*. Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Proc Natl Acad Sci USA 2014;111:15438-43.

6. He S*, Liang Y , Shao F , Wang X*. Toll-like receptors activate programmed

1. necrosis in macrophages through a receptor-interacting kinase-3 mediated

2. pathway. Proc Natl Acad Sci USA 2011;108:20054-59.

7. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009;137:1100-11.

专利

1. Wang X, He S, Wang L. Necrosis assay, 2009，US7622106

2. Lei X, He S, Li C, Dong T, Sesquiterpenoids, 2017, US9670226B2