课题组长：宋耀华

课题组目前主要研究恶性贫血和骨髓增生异常综合征的发生机理，研究课题包括：1.寻找导致恶性贫血和骨髓增生异常综合征的共同遗传标记；2. 发现新的信号转导分子和通路。所从事的研究已发现IGF-1 信号传导障碍是心源性恶液质的主要病因。相关成果已经发表在J Clin Invest 等本领域国际一流期刊上。入选江苏省“双创团队”、苏州工业园区第九届“科技领军人才”等。

代表性成果 Representative Achievements：

论文

1. Shen C# Zhou J#, Wang X#, Yu XY#, Liang C#, Liu B#, Pan X#, Zhao Q, Song JL, Wang J, Bao M, Wu C, Li Y*, Song YH*. Angiotensin-II-induced Muscle

1. Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway. EBioMedicine 2017;16:238-250.

2. Song C#, Song YH#*, Xie Y#, Wang X#, Wang Y#, Wang C#, Liu S, Xue S, Li Y, Liu B, Tang Z, Chen W, Song J, Amin HM, Zhou J*. Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway. Oncotarget 2017;8:76279-89.

3. Ping N#, Sun A#, Song Y#, Wang Q#, Yin J, Cheng W, Xu Y, Wen L, Yao H, Ma L, Qiu H, Ruan C, Wu D*, Chen S*. Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia. Leukemia 2017;31:195-202.

4. Li Y*, Zhou J, Song YH, Yu XY. Dominant and recessive imprinting of exosomes from parent cells. Nat Rev Cardiol 2017;14:491.

5. Wang J, Zhao M, Xiao J, Wu M, Song Y*, Yin Y*. E-Cadherin, CD44v6, and Insulin-Like Growth Factor-II mRNA-Binding Protein 3 Expressions in Different Stages of Hydatidiform Moles. J Biochem Mol Toxicol 2016;30:455-61.

6. Tang X#, Song YH#, Sun A, Ruan C, Wu D*. Successful treatment of relapsed acute myeloid leukemia without chemotherapy. J Clin Oncol 2016;34:e117-9.

7. Wang X#, Zhi Q#, Liu S#, Xue S#, Shen C, Li Y, Wu C, Tang Z, Chen W, Song JL, Bao M, SongY*, Zhou J*. Identification of specific biomarkers for gastric adenocarcinoma by ITRAQ proteomic approach. Sci Rep 2016;6:38871.

8. Zhao Q#, Yang S#, Wang J#, Zhou J, Xing S, Shen C, Wang X, Yue Y, Song J, Chen M, Wei Y, Zhou Q, Dai T, Song YH*. TNF alpha inhibits myogenic differentiation of C2C12 cells through NF-κB activation and impairment of IGF-1 signaling pathway. Biochem Biophys Res Commun 2015;458:790-5.