课题组长：赵昀

课题组主要致力于研究维持慢性粒细胞白血病（Chronic myeloid leukemia，CML）干细胞生存的分子机制，期望能为改善该疾病的治疗提供新策略和靶标。相关研究已获得6 项国家自然科学基金项目的资助，并参与1 项“973”项目。在鉴定新的白血病相关原癌基因和抑癌基因研究中取得阶段性进展。

代表性成果 Representative Achievements：

论文

1. Ma W#, Liu J#, Xie J#, Zhang X, Zhou H, Yao H, Zhang W, Guo D, Zhu L, Xiao L, Wu D, Xu H, Chen S*, Zhao Y*. Modulating the growth and imatinib sensitivity of chronic myeloid leukemia stem/progenitor cells with pullulan/microRNA anoparticles in vitro. J Biomed Nanotechnol 2015;11:1961-74.

2. Zhang X#, Ma W#, Cui J#, Yao H, Zhou H, Ge Y, Xiao L, Hu X, Liu BH, Yang J, Li YY, Chen S, Eaves CJ, Wu D*, Zhao Y*. Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia. Oncogene 2015;34(23):3000-10.

3. Zhou H#, Ge Y#, Sun L#, Ma W, Wu J, Zhang X, Hu X, Eaves CJ, Wu D*, Zhao Y*. Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth. PLoS One 2014;9:e86195.

4. Guo D, Zhu L, Huang Z, Zhou H, Ge Y, Ma W, Wu J, Zhang X, Zhou X, Zhang Y, Zhao Y*, Gu N*.Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions. Biomaterials 2013;34:7884-94.