课题组长：武艺

课题组的研究领域包括：1. 血栓与止血：血小板和凝血系统活化的分子与细胞机制，及血栓形成启动过程的整合调控；2. 血浆接触活化系统调控血管稳态与固有免疫的作用；3. 凋亡细胞吞噬天然免疫的机制。其研究受国家自然科学基金项目、科技部973 前期项目、教育部高等学校博士学科点专项和日中医学协会共同研究项目等资助，曾获美国NIH 新研究者奖和日本加藤纪念生命科学基金会奖等。相关成果在JCI、JEM、Blood 等国际学术期刊发表50 余篇。目前担任Thrombosis Journal 杂志副主编，Thrombosis Research 和Cell Communication and Signaling 杂志编委。

代表性成果 Representative Achievements：

论文

1. Wang B, Yang A, Zhao Z, He C, Liu Y, Colman RW, Dai J, Wu Y*.The Plasma Kallikrein -Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice. Front Immunol 2018;9:21.

2. Zhou J#, Wu Y#*, Chen F, Wang L, Rauova L, Hayes VH, Poncz M, Li H, Liu T, Liu J, Essex DW*. The disulfide isomerase ERp72 supports arterial thrombosis in mice. Blood 2017;130:817-28.

3. Yang A#, Xie Z#, Wang B#, Colman RW, Dai J, Wu Y *. An essential role of highmolecular-weight kininogen in endotoxemia. J Exp Med 2017;214(9):2649-2670.

4. Yang A#, Zhou J#, Wang B, Dai J, Colman RW, Song W, Wu Y*. A critical role for plasma kallikrein in the pathogenesis of autoantibody-induced arthritis. FASEB J 2017;31:5419-31.

5. Yang A#, Chen F#, He Chao, Zhou J, Lu Y, Dai J, Birge RB, Wu Y*. The Procoagulant Activity of Apoptotic Cells Is Mediated by Interaction with Factor XII. Front Immunol 2017;8:1188.

6. Zhou J#, Wu Y#*, Wang L, Rauova L, Hayes VH, Poncz M, Essex DW*. The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. J Clin Investigation 2015;125(12):4391-406.

7. Yang A, Dai J, Xie Z, Colman RW, Wu Q, Birge RB, Wu Y*. High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis. J Immunol 2014;192:4398-408.

8. Wang L#, Wu Y#*, Zhou J, Ahmad SS, Mutus B, Garbi N, H?mmerling G, Liu J, Essex DW*. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin. Blood 2013;122:3642-50.

专利

一种杂交瘤细胞及其产生的单克隆抗体和应用；武艺，周俊松，陈凤梧；ZL2014.1.0184173.3